MICRODRIFT - RAPID AND EFFICIENT IR ANALYSIS OF SOLID-PHASE ORGANIC-CHEMISTRY REACTIONS

Diffuse reflectance FTIR (DRIFT) analyses of Solid Phase Organic Chemi stry (SPOC) resins using a DRIFT cup with a reduced sample volume, the DRIFT microcup, are presented. The use of this microcup only requires <1 mg of resin. The spectra are comparable with DRIFT spectra acquire d using a conventional DRIFT accessory, but the amount of sample consu med in analysis is appreciably less. The use of a DRIFT accessory with a smaller sample compartment strongly reduces the time required for n itrogen purging. This, combined with the acquisition of spectra with a lower resolution and fewer scans, results in an over tenfold reductio n of total analysis time without the loss of relevant spectral informa tion. This technique is a useful alternative and/or complement to IR m icroscopic analysis of SPOC resins and other IR sampling techniques. A number of reactions analysed by this technique is presented.