DIASTEREO-SELECTIVE AND ENANTIOSELECTIVE SYNTHESIS OF (- AND (-)-CIS-2-AMINOCYCLOBUTANOLS())

The hitherto unknown (+)- and (-)-cis-2-aminocyclobutanols 6a,b and 7a ,b, as well as the corresponding benzyloxycyclobutanamines 8a,b, have been synthesized by means of asymmetric reductive amination, with de v alues of 100% and ee values ranging from 96.9 to 99.8%. The relative c is configuration has been established by NO experiments, whereas the a bsolute stereochemistry has been deduced from the CD spectra of the co rresponding salicylidene derivatives and confirms the like induction a t C-1.