PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS

Authors
DUNCIA JV SANTELLA JB HIGLEY CA VANATTEN MK WEBER PC ALEXANDER RS KETTNER CA PRUITT JR LIAUW AY QUAN ML KNABB RM WEXLER RR
Citation
Jv. Duncia et al., PYRAZOLES, 1,2,4-TRIAZOLES, AND TETRAZOLES AS SURROGATES FOR CIS-AMIDE BONDS IN BORONATE ESTER THROMBIN INHIBITORS, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 775-780
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
7
Year of publication
1998
Pages
775 - 780
Database
ISI
SICI code
0960-894X(1998)8:7<775:P1ATAS>2.0.ZU;2-W
Abstract
Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrog ates for cis-amide bonds in a series of boronate ester thrombin inhibi tors. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by E lsevier Science Ltd. All rights reserved.