AMYGDALIN BINDS TO THE CD4 RECEPTOR AS SUGGESTED FROM MOLECULAR MODELING STUDIES

Authors
LLORENS O FILIZOLA M SPISANI S MARASTONI M HERRANZ C PEREZ JJ
Citation
O. Llorens et al., AMYGDALIN BINDS TO THE CD4 RECEPTOR AS SUGGESTED FROM MOLECULAR MODELING STUDIES, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 781-786
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
7
Year of publication
1998
Pages
781 - 786
Database
ISI
SICI code
0960-894X(1998)8:7<781:ABTTCR>2.0.ZU;2-0
Abstract
The geometrical features of the proposed bioactive conformation of pep tide T assessed by computational methods in a previous study, together with available structure-activity studies on peptide T, led us to pro pose a pharmacophore for the CD4-peptide T interaction. Subsequent, da ta base searching permitted us to identify amygdalin as a peptide T pe ptidomimetic. (C) 1998 Elsevier Science Ltd. All rights reserved.