AN APPROACH TO USE AN UNUSUAL ADENOSINE TRANSPORTER TO SELECTIVELY DELIVER POLYAMINE ANALOGS TO TRYPANOSOMES

Authors
TYE CK KASINATHAN G BARRETT MP BRUN R DOYLE VE FAIRLAMB AH WEAVER R GILBERT IH
Citation
Ck. Tye et al., AN APPROACH TO USE AN UNUSUAL ADENOSINE TRANSPORTER TO SELECTIVELY DELIVER POLYAMINE ANALOGS TO TRYPANOSOMES, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 811-816
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
7
Year of publication
1998
Pages
811 - 816
Database
ISI
SICI code
0960-894X(1998)8:7<811:AATUAU>2.0.ZU;2-D
Abstract
In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared inter act specifically with the adenosine transporter, some with a similar e fficiency to berenil, a known substrate. (C) 1998 Elsevier Science Ltd . All rights reserved.