STRUCTURE-BASED DESIGN AND SYNTHESIS OF A SERIES OF HYDROXAMIC ACIDS WITH A QUATERNARY-HYDROXY GROUP IN P1 AS INHIBITORS OF MATRIX METALLOPROTEINASES

Authors
JACOBSON IC REDDY PG WASSERMAN ZR HARDMAN KD COVINGTON MB ARNER EC COPELAND RA DECICCO CP MAGOLDA RL
Citation
Ic. Jacobson et al., STRUCTURE-BASED DESIGN AND SYNTHESIS OF A SERIES OF HYDROXAMIC ACIDS WITH A QUATERNARY-HYDROXY GROUP IN P1 AS INHIBITORS OF MATRIX METALLOPROTEINASES, Bioorganic & medicinal chemistry letters, 8(7), 1998, pp. 837-842
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
7
Year of publication
1998
Pages
837 - 842
Database
ISI
SICI code
0960-894X(1998)8:7<837:SDASOA>2.0.ZU;2-8
Abstract
Examination of the S1 area of the active site of pro-stromelysin has l ed us to the design of novel and potent inhibitors of matrix metallopr oteinases containing constrained quaternary-hydroxy group at pi. The s ynthesis and biological activity of these compounds with variations at P1', P2', and P3' will be described. (C) 1998 The DuPont Merck Pharma ceutical Company. Published by Elsevier Science Ltd. All rights reserv ed.