EFFECTS OF SECONDARY FLOW CAUSED BY A CURVED CHANNEL ON PLASMA-PROTEIN ADSORPTION TO ARTIFICIAL SURFACES

The effects of secondary flow induced by a curved channel on fibrinoge n deposition and replacement on a glass surface were studied. Platelet adhesion to surface-bound fibrinogen was also studied to indicate how secondary flaw may affect thrombogenesis on artificial surfaces. A sa line pre-wetted channel with straight and curved sections was exposed to flowing plasma at a Reynolds number of 28.6. Results show that fibr inogen deposited on the surface at a shear rate of 175 s(-1) was repla ced faster in regions of secondary flow (Dean numbers from 11 to 19) t han in adjacent regions of shear flow. Platelets adhered only to those surfaces where fibrinogen had been detected.