ECCRINE SYRINGOFIBROADENOMA - REPORT OF A CASE AND ANALYSIS OF CYTOKERATIN EXPRESSION

Eccrine syringofibroadenoma (ESFA) is a rare disorder which shows diff erentiation toward the eccrine sweat apparatus. There is a controversy concerning the pathogenesis and precise differentiation of this tumor . We report a case of ESFA and its differentiation pattern by an analy sis of cytokeratin expression. Using paraffin-embedded materials, hist opathological and immunohistochemical studies were performed. Staining patterns of the luminal, peripheral, and inner cells of the tumor str ands closely matched or mimicked those of the luminal, outer and inter mediate cells of the normal eccrine dermal duct, respectively. The cas e of ESFA reported revealed a pattern of differentiation suggestive of an eccrine duct origin.