ANTIVIRAL ACTIVITY OF TUMOR-SUPPRESSOR PATHWAYS - CLUES FROM MOLECULAR PIRACY BY KSHV

A common feature of many tumor viruses is that they possess genes that produce specific proteins to inhibit major cellular tumor-suppressor pathways. Despite intensive studies, the reasons why these diverse and unrelated viruses have independently evolved oncogenes remains obscur e. Kaposi-sarcoma-associated herpesvirus (KSHV or HHV8) has pirated a number of recognizable cellular genes that are key to cell survival an d proliferation In this review we provide an overview of the known act ivities of these viral genes and show that many of these pirated prote ins affect the same cellular pathways targeted by other, unrelated tum or viruses. We speculate that tumor-suppressor pathways are used by th e cell as a primary defense against persistent virus infection in addi tion to their well-known activity in regulating cell proliferation.