CONCENTRATIONS OF SULFADOXINE AND TRIMETHOPRIM IN PLASMA, LYMPH FLUIDS AND SOME TISSUES 24 H AFTER INTRAMUSCULAR ADMINISTRATION TO ANGORA-GOATS

This study was carried out to determine the concentrations of sulfadox ine and trimethoprim in plasma, lymph, and some tissues in goats after administration of a single recommended therapeutic dose. Five healthy , adult Angora goats were used. The drug combination, containing 200 m g sulfadoxine and 40 mg trimethoprim per millilitre, was given as a si ngle IM injection at the recommended dose level, 15 mg/kg body weight for sulfadoxine and 3 mg/kg body weight for trimethoprim. The goats we re slaughtered 24 hours after drug administration and samples were tak en from liver, bone marrow, pelvic limb muscles, hepatic, thoracic duc t, and the pelvic limb lymph fluids for analysis of drug concentration s by HPLC. The concentrations of trimethoprim in bone marrow, liver, p elvic limb muscles, hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were found to be 6, 5, 4, 2, 5 and 15 times higher than th ose of plasma, respectively. Although the sulfadoxine concentrations i n bone marrow, pelvic limb muscles, and liver were 2, 3 and 2 times hi gher than the plasm concentrations, respectively, the sulfadoxine conc entrations in hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were lower than those of plasma. The results show that the trime thoprim concentrations in lymph fluids were quite similar to those in tissues. However, the sulfadoxine concentrations in lymph fluids were different in each tissue.