BRONCHIOLITIS OBLITERANS ORGANIZING PNEUM ONIA ASSOCIATED WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

We report a case of a 35 year-old woman with idiopathic thrombocytopen ic purpura (ITP) who, under treatment with immunosuppressive drugs, de veloped bilateral interstitial pulmonary disease. Previously she had b een splenectomized and treated with corticosteroids and cyclosporin. D uring the clinical course, the patient developed alterations of the he patogram and presented a positive serology for Epstein-Barr virus. The lung biopsy showed the histologic pattern of obliterative bronchiolit is, interstitial inflammatory infiltration and intraalveolar pneumonia (BOOP). We could not find in the literature a previous report in whic h ITP was associated with BOOP. Of interest was the spontaneous remiss ion of the pulmonary disease after suppression of cyclosporin and posi tive serology for Epstein-Barr virus.