Citation
L. Fudala et Ah. Lewin, PREPARATION OF C-14-LABELED ORGANOPHOSPHATE PESTICIDES - CHLORFENVINPHOS, Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 261-266
Citations number
9
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
Journal title
ISSN journal
03624803
Volume
41
Issue
4
Year of publication
1998
Pages
261 - 266
Database
ISI
SICI code
0362-4803(1998)41:4<261:POCOP->2.0.ZU;2-F
Abstract
Synthesis of [vinyl-C-14]chlorfenvinphos, utilizing [C-14]iodomethane
as the source of the label, was accomplished in 28% radiochemical yiel
d by the methylation of 2,4-dichlorobenzoyl chloride, chlorination of
the resulting [C-14]-2,4-dichloroacetophenone, and condensation of the
product with triethylphosphite. The product, isolated as a mixture of
E and Z isomers (3.6 and 96.3%, respectively), was obtained in >99% p
urity and had specific activity 20 mCi/mmol.