SYNTHESIS OF [H-3]-ILLUDIN-S, [H-3]-ACYLFULVENE, [H-3]AND[C-14]HYDROXYMETHYLACYLFULVENE (MGI-114)

Authors
MCMORRIS TC YU JA HERMAN DM KELNER MJ DAWE R MINAMIDA A
Citation
Tc. Mcmorris et al., SYNTHESIS OF [H-3]-ILLUDIN-S, [H-3]-ACYLFULVENE, [H-3]AND[C-14]HYDROXYMETHYLACYLFULVENE (MGI-114), Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 279-285
Citations number
11
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
41
Issue
4
Year of publication
1998
Pages
279 - 285
Database
ISI
SICI code
0362-4803(1998)41:4<279:SO[[[>2.0.ZU;2-9
Abstract
Tritiated derivatives of the toxic sesquiterpene illudin S (1) have be en prepared by fermentation of Omphalotus illudens in the presence of [H-3]-sodium acetate. [H-3]-illudin S was converted to antitumor [H-3] -acylfulvene (4) by treatment with dilute sulfuric acid. Antitumor [C- 14]-hydroxymethylacylfulvene (5) was best prepared by reacting acylful vene with [C-14]-paraformaldehyde in dilute sulfuric acid.