SYNTHESIS OF THE DEUTERATED COMPOUNDS DIETHYL-4-D-PYRIDINE-2,6-DICARBOXYLATE AND DIETHYL-3,4,5-D-3-PYRIDINE-2,6-DICARBOXYLATE BY CATALYTIC REDUCTIVE DEBROMINATION

Citation
W. Herdering et Hj. Kruger, SYNTHESIS OF THE DEUTERATED COMPOUNDS DIETHYL-4-D-PYRIDINE-2,6-DICARBOXYLATE AND DIETHYL-3,4,5-D-3-PYRIDINE-2,6-DICARBOXYLATE BY CATALYTIC REDUCTIVE DEBROMINATION, Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 301-307
Citations number
17
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
ISSN journal
03624803
Volume
41
Issue
4
Year of publication
1998
Pages
301 - 307
Database
ISI
SICI code
0362-4803(1998)41:4<301:SOTDCD>2.0.ZU;2-G
Abstract
The synthesis of the mono-and trideutero compounds diethyl-4-D-pyridin e-2,6-dicarboxylate (4) and diethyl-3,4,5-D-3-pyridine-2,6-dicarboxyla te (5) was achieved under a deuterium gas atmosphere by reductive debr omination of diethyl-4-bromopyridine-2,6-dicarboxylate (1) and diethyl -3,4,5-tribromopyridine-2,6-dicarboxylate (2), respectively, using pal ladium black as catalyst and dichloromethane as solvent. The deuterium incorporation at the specified positions exceeded 95%.