SYNTHESIS OF THE DEUTERATED COMPOUNDS DIETHYL-4-D-PYRIDINE-2,6-DICARBOXYLATE AND DIETHYL-3,4,5-D-3-PYRIDINE-2,6-DICARBOXYLATE BY CATALYTIC REDUCTIVE DEBROMINATION
W. Herdering et Hj. Kruger, SYNTHESIS OF THE DEUTERATED COMPOUNDS DIETHYL-4-D-PYRIDINE-2,6-DICARBOXYLATE AND DIETHYL-3,4,5-D-3-PYRIDINE-2,6-DICARBOXYLATE BY CATALYTIC REDUCTIVE DEBROMINATION, Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 301-307
Citations number
17
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
The synthesis of the mono-and trideutero compounds diethyl-4-D-pyridin
e-2,6-dicarboxylate (4) and diethyl-3,4,5-D-3-pyridine-2,6-dicarboxyla
te (5) was achieved under a deuterium gas atmosphere by reductive debr
omination of diethyl-4-bromopyridine-2,6-dicarboxylate (1) and diethyl
-3,4,5-tribromopyridine-2,6-dicarboxylate (2), respectively, using pal
ladium black as catalyst and dichloromethane as solvent. The deuterium
incorporation at the specified positions exceeded 95%.