SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - 2-[F-18]FLUORO-3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE (2-[F-18]A-85380)

Authors
HORTI AG KOREN AO RAVERT HT MUSACHIO JL MATHEWS WB LONDON ED DANNALS RF
Citation
Ag. Horti et al., SYNTHESIS OF A RADIOTRACER FOR STUDYING NICOTINIC ACETYLCHOLINE-RECEPTORS - 2-[F-18]FLUORO-3-(2(S)-AZETIDINYLMETHOXY)PYRIDINE (2-[F-18]A-85380), Journal of labelled compounds & radiopharmaceuticals, 41(4), 1998, pp. 309-318
Citations number
23
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
41
Issue
4
Year of publication
1998
Pages
309 - 318
Database
ISI
SICI code
0362-4803(1998)41:4<309:SOARFS>2.0.ZU;2-B
Abstract
The radiochemical synthesis of 2-[F-18]fluoro-3-(2(S)-azetidinylmethox y)pyridine (2-[F-18]A-85380, [F-18](1) under bar 1) was accomplished b y Kryptofix(R) 222 assisted nucleophilic no-carrier-added [F-18]fluori nation of 2-iodo-3-((1-tert-butoxycarbonyl-2 -(S)-azetidinyl)methoxy)p yridine, (2) under bar followed by acidic deprotection. The average ra diochemical yield was 10% and the average specific radioactivity was 1 050 mCi/mu mol, calculated at end-of-synthesis (EOS).