INHIBITION OF LEUKOCYTE ADHESION - AN ALTERNATIVE MECHANISM OF ACTIONFOR ANTIINFLAMMATORY DRUGS

It has been widely accepted that the mechanism of action of nonsteroid al anti-inflammatory drugs (NSAIDs) is the inhibition of prostaglandin synthesis. However, a significant body of evidence suggests that NSAI Ds have additional anti-inflammatory mechanisms of action. Here, Feder ico Diaz-Gonzalez and Francisco Sanchez-Madrid discuss novel effects o f NSAIDs on leukocyte adhesion pathways that may help in the developme nt of new anti-inflammatory agents that selectively block cell adhesio n molecules.