Activated protein C resistance is the most common hereditary coagulati
on abnormality and is caused by the factor V Leiden mutation, A newbor
n who developed seizures within hours after delivery and was found to
have a bihemispheric stroke is described, This patient, determined to
be heterozygous for factor V Leiden, is the first reported case of neo
natal stroke associated with this common mutation. (C) 1998 by Elsevie
r Science Inc. All rights reserved.