The aims of this study were to examine long-term survival in a populat
ion-based sample of spinal cord injury (SCI) survivors in Great Britai
n, identify risk factors contributing to deaths and explore trends in
cause of death over the decades following SCI. Current survival status
was successfully identified in 92.3% of the study sample. Standardise
d mortality ratios (SMRs) were calculated and compared with a similar
USA study. Relative risk ratio analysis showed that higher mortality r
isk was associated with higher neurologic level and completeness of sp
inal cord injury, older age at injury and earlier year of injury. For
the entire fifty year time period, the leading cause of death was rela
ted to the respiratory system; urinary deaths ranked second followed b
y heart disease related deaths, but patterns in causes of death change
d over time. In the early decades of injury, urinary deaths ranked fir
st, heart disease deaths second and respiratory deaths third. In the l
ast two decades of injury, respiratory deaths ranked first, heart rela
ted deaths were second, injury related deaths ranked third and urinary
deaths fourth. This study also raises the question of examining alter
native neurological groupings for future mortality risk analysis.