ANTIFUNGAL LIGNANS FROM THE ARILS OF VIROLA-OLEIFERA

Arils of Virola oleifera (Myristicaceae) contain two 2,7'-cyclolignans : galbulin, and 4-hydroxy-5,3',4'-trimethoxy-2,7'-cyclolignan; five li gnan-7-ols: oleiferin-B, 3,4,3',4'-tetramethoxylignan-7-ol, oleiferin- F, oleiferin-G, and oleiferin-H and one epoxylignan: verrucosin. Four of the isolates are new. All of the lignan-7-ols and verrucosin showed antifungal activity against Cladosporium sphaerospermum at a minimum amount of 25 mu g, and the lignan-7-ols oleiferin-B and oleiferin-G sh owed antifungal activity against C. cladosporoides at a minimum amount of 10 mu g. (C) 1998 Elsevier Science Ltd. All rights reserved.