There is controversy whether idiopathic mid-line destructive disease r
emains a valid entity, some authors considering that such cases are un
recognized malignant lymphoma or Wegener's disease. A case is presente
d in which numerous nasal biopsies over several years failed to show e
vidence of either lymphoma or Wegener's disease. Molecular genetic ana
lysis of archival tissue did not demonstrate a monoclonal lymphoid pop
ulation. It is proposed that idiopathic mid-line destructive disease r
emains a valid description in a small number of cases.