K. Frey et al., THE RECOVERY PROFILE OF HYPERBARIC SPINAL-ANESTHESIA WITH LIDOCAINE, TETRACAINE, AND BUPIVACAINE, REGIONAL ANESTHESIA AND PAIN MEDICINE, 23(2), 1998, pp. 159-163
Background and Objectives. Surgical procedures previously considered t
oo lengthy for the ambulatory surgery setting are now being performed
during spinal anesthesia. The complete recovery profile of tetracaine
and bupivacaine are now of interest but are not available in the liter
ature. This study was conducted to compare times to ambulation, voidin
g, and complete block resolution, as well as the incidence of back and
radicular pain, after spinal anesthesia with lidocaine, bupivacaine,
and tetracaine. Methods. Twelve adult volunteers underwent spinal anes
thesia on three separate occasions with three local anesthetics (lidoc
aine 100 mg, bupivacaine 15 mg, and tetracaine 15 mg in hyperbaric sol
utions) in random order and in a double-blind fashion. A 24-gauge Spro
tte spinal needle was placed at the L2-3 interspace. The level of anal
gesia to pinprick was determined moving cephalad in the midclavicular
line until a dermatome was reached at which the prick felt as sharp as
over an unblocked dermatome. One dermatome caudad to this point was r
ecorded every 5 minutes as the level of analgesia. We also recorded th
e times to voiding, unassisted ambulation, and complete resolution of
sacral anesthesia. Results. There was no difference between tetracaine
and bupivacaine in time taken for two-and four-segment regression of
the analgesia level. However, times to ambulation and complete resolut
ion of the block were significantly shorter with bupivacaine then with
tetracaine. With lidocaine, times to four-segment regression, ambulat
ion, voiding, and complete regression of the block were significantly
shorter than with bupivacaine and tetracaine. Time to two-segment regr
ession did not differ among local anesthetics. Back and radicular pain
symptoms were reported by three subjects after lidocaine subarachnoid
block but not after tetracaine or bupivacaine. Conclusion. Among indi
vidual subjects, lidocaine exhibited the shortest recovery profile. Ho
wever, the recovery profiles of the three anesthetics were very variab
le between subjects. Time to meeting discharge criteria after bupivaca
ine or tetracaine was faster in a few subjects than that after lidocai
ne in other subjects. For ambulatory anesthesia, times to two-and four
-segment regression do not accurately predict time to readiness for di
scharge after spinal anesthesia.