THE BACILLUS-SUBTILIS GALE GENE IS ESSENTIAL IN THE PRESENCE OF GLUCOSE AND GALACTOSE

Authors
KRISPIN O ALLMANSBERGER R
Citation
O. Krispin et R. Allmansberger, THE BACILLUS-SUBTILIS GALE GENE IS ESSENTIAL IN THE PRESENCE OF GLUCOSE AND GALACTOSE, Journal of bacteriology, 180(8), 1998, pp. 2265-2270
Citations number
25
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
180
Issue
8
Year of publication
1998
Pages
2265 - 2270
Database
ISI
SICI code
0021-9193(1998)180:8<2265:TBGGIE>2.0.ZU;2-I
Abstract
Bacillus subtilis is unable to grow by consuming galactose because it is unable to transport it into the cell. The transcription of galE is not influenced by galactose but is repressed by glucose. Galactose is toxic for galE-negative bacteria because it results in elevated levels of metabolic intermediates. These negative effects are reduced in gal K and galT mutants. Glucose is also toxic for galE-negative strains.