SUPPLEMENTAL THERAPY IN ISOLATED VITAMIN-E-DEFICIENCY IMPROVES THE PERIPHERAL NEUROPATHY AND PREVENTS THE PROGRESSION OF ATAXIA

A 24-year-old male, who suffered since childhood from a progressive fo rm of ataxia associated with peripheral neuropathy, was found severely deficient in serum vitamin E. He walked with bilateral aid and presen ted severe dysmetria of the limbs and dysarthric speech; muscular stre ngth and trophism were slightly diminished in the distal muscles of fo ur limbs and there was hypotonia of the arms; he presented absent deep tendon reflexes, bilateral Babinski's sign, reduced proprioception at four limbs, pes cavus and fasciculations of the tongue. Intestinal fa t malabsorption and other gastrointestinal or haematological condition s associated with deficiency of this vitamin were ruled out. In this p atient, after 2 years of a daily supplement of high doses of vitamin E , a further progression of the disease was not observed and, moreover, the neurophysiological characteristics of his neuropathy appeared cle arly improved. A longitudinal evaluation of serum vitamin E levels sho wed values in the normal range after 13 months of therapy. The patient had molecular genetic analysis of chromosome 8 and was found homozygo us for the unusual mutation 513insTT in the ol-tocopherol transfer pro tein gene. (C) 1998 Elsevier Science B.V.