MASSIVE PROTEINURIA AS A MAIN MANIFESTATION OF PRIMARY ANTIPHOSPHOLIPID SYNDROME

Renal involvement in antiphospholipid syndrome (APS) is increasingly r eported. So far, massive proteinuria as the principal feature of prima ry APS (PAPS) has not been well documented. We describe 3 patients wit h PAPS and massiv proteinuria. Renal biopsy was performed in all 3, an d features consistent with membranous and focal segmental glomerulopat hy were disclosed. These histological lesions were not yet reported in PAPS. We conclude that the spectrum of renal lesions in PAPS is diver se and that it should be considered in the differential diagnosis of p atients with massive proteinuria.