Objective: Lower extremity alignment factors, including tibiofemoral a
ngle, quadriceps angle (Q-angle), and limb length discrepancies, are c
ommonly thought to be clinically relevant as contributing factors to o
veruse injuries of the lower extremities. To explore the scientific ra
tionale for these clinical beliefs, we conducted a review of the avail
able English language literature from 1966 to July 1997 relating overu
se injury to lower extremity alignment. Data Sources: MEDLINE was sear
ched for medical subject headings and title key words to locate publis
hed works relating lower extremity morphologic characteristics to risk
of overuse injury. Additional references were reviewed from reprint c
ollections and reference lists of published work. Data Extraction and
Synthesis: Relevant studies were reviewed for strengths and weaknesses
in design, analysis, and conclusions. Synthesis across studies concen
trated on commonalities and differences of methods in definition of ex
posure and outcome variables. Main Results: Six population-based studi
es have been conducted evaluating some aspect of lower extremity align
ment as a risk factor for overuse injury. Three of these studies evalu
ated military recruits in basic training, two studied mixed groups of
athletes, and one studied folk dancers. The time frame across studies
ranged from 12 weeks to 52 weeks. A key finding was the considerable v
ariation in the measure of lower limb alignment used as the exposure v
ariable, as well as the method of measurement used to quantify the exp
osure. Some studies relied on visual examination, whereas others used
digitized photographic techniques. Moreover, each study varied in the
definition used for overuse injury, outcomes ranged from self-reported
cases of shin splints to radiographic confirmation of stress fracture
. Five of the six studies evaluated some aspect of foot morphology, wh
ereas only one evaluated full leg alignment parameters. Conclusions: R
esults were conflicting but, in general, did not support clinical beli
efs of the detrimental effects of decreased longitudinal foot arch and
varus tibiofemoral alignment as risk factors for lower extremity over
use injury. Differences in methodologic rigor and outcome definition p
revent a meaningful synthesis of existing work. Directions for future
research are suggested.