GASTROINTESTINAL-TRACT AS A MAJOR SITE OF CD4-CELL DEPLETION AND VIRAL REPLICATION IN SIV INFECTION( T)

Human and simian immunodeficiency virus (HIV and SIV) replicate optima lly in activated memory CD4(+) T cells, a cell type that is abundant i n the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4(+) T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4(+) T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this sit e. The intestine appears to be a major target for SIV replication and the major site of CD4(+) T cell loss in early SIV infection.