ANALYSIS OF ANTIGEN RECEPTOR SIGNALING USING MOUSE GENE TARGETING

Gene targeting in mice has enabled the study of antigen receptor signa lling in primary lymphocytes. Furthermore, it has provided the tools t o directly assess the function of individual signalling proteins by mu tation of the genes that code for them. Some of the results that gene targeting has produced have confirmed previous views of the function o f particular proteins. Others have given surprising results and overtu rned accepted viewpoints, (C) Current Biology Ltd ISSN 0955-0674.