THE ABSORPTION OF DILINOLEOYL-PHOSPHATIDY LCHOLINE AFTER ORAL-ADMINISTRATION

Essential(R) and Lipostabil(R) contain ''essential'' phospholipids fro m the soybean, mainly 1,2-dilinoleoyl-phosphatidylcholine (GAS 998-06- 1, DLPC) which is considered as the main active ingredient. A single o ral dose of d(15)-DLPC loaded with deuterium 9 times in the choline an d 6 times in the linoleic acid Of the 1-position was given to voluntee rs Sera from 11 blood samples taken within 48 h after application were examined by means of mass spectrometry with regard to d(9)-choline an d d(6)-linoleic acid in the 1- and 2-position of serum phosphatidylcho lines (PC) as well as in the serum triglycerides. d(9)-choline, i.e. t he total of d(15)-PC and d(9)-PC, showed maximum values of 5.6 % of th e total serum PC concentration. Normally, about 1.3 % of PC in the hum an serum is DLPC. Serum 1-linoleoyl-PC was increased by 32-40 % after oral application of d(15)-DLPC. A minor uptake of d(6)-linoleic acid i nto the 2-position of serum PC, which is rich in linoleic acid, and in to the serum triglycerides was observed with peak values of 2.3 % and 6.1 %, resp. The uptake of polyunsaturated PC species like DLPC and 1- linoleoyl-PC into the liver after oi al application of drugs containin g such species in high amounts like ''essential'' phospholipids with a bout 50 % of DLPC let expect therapeutic effects on membranes into whi ch this special species is incorporated.