COMPARISON OF FOSFOMYCIN AND TEICOPLANIN IN SERUM BACTERICIDAL ACTIVITY AGAINST STAPHYLOCOCCI

A serum bactericidal test was established employing human sera of volu nteers after intravenous administration of fosfomycin (CAS 23155-02-4) and teicoplanin (CAS 61036-62-2) against 40 staphylococcal strains (2 0 Staphylococcus aureus and 20 coagulase-negative staphylococci, 10 of each group being susceptible and 10 being resistant to oxacillin). Me dian ser um inhibitory titres were highest for fosfomycin against oxac illin-susceptible Staphylococcus aureus. In the three other groups of strains, the activity of fosfomycin was comparable to that of teicopla nin. The killing curves showed over 99 % killing within 24 h for both antibiotics Here, fosfomycin exerted a rapid killing activity within 4 -6 it and was more effective in bacterial growth reduction. It can be concluded that fosfomycin and teicoplanin exerted comparable serum bac tericidal antibacterial activity against staphylococci.