CURRENT DEVELOPMENTS IN THE MOLECULAR-GENETICS OF THE POLYCYSTIC-OVARY-SYNDROME

Authors
FRANKS S GHARANI N WATERWORTH D BATTY S WHITE D WILLIAMSON R MCCARTHY M
Citation
S. Franks et al., CURRENT DEVELOPMENTS IN THE MOLECULAR-GENETICS OF THE POLYCYSTIC-OVARY-SYNDROME, Trends in endocrinology and metabolism, 9(2), 1998, pp. 51-54
Citations number
41
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Trends in endocrinology and metabolism → ACNP
ISSN journal
10432760
Volume
9
Issue
2
Year of publication
1998
Pages
51 - 54
Database
ISI
SICI code
1043-2760(1998)9:2<51:CDITMO>2.0.ZU;2-Q
Abstract
Polycystic ovary syndrome (PCOS) is most likely a complex trait with a n oligogenic basis. In this article, we present evidence from molecula r genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyper-androgenism. Variation in the regulatory region of the insulin gene also appears to contribute to the development of PCOS.