L. Ibanez et al., INSULIN-RESISTANCE, PREMATURE ADRENARCHE, AND A RISK OF THE POLYCYSTIC-OVARY-SYNDROME (PCOS), Trends in endocrinology and metabolism, 9(2), 1998, pp. 72-77
Timing of puberty and final height are usually normal in girls with a
history of premature adrenarche. However, these patients show an incre
ased frequency of ovarian hyperandrogenism, hyperinsulinism and dyslip
emia at adolescence. The hyperinsulinemia and lipid disturbances can o
ften be detected in the prepubertal period, recommending long-term fol
low-up of these patients into adulthood.