BENZODIAZEPINE-INDUCED PERSISTING AMNESTIC DISORDER - ARE OLDER ADULTS AT RISK

Currently there are approximately 31.5 million Americans 65 years and older. This number is expected to reach 39.3 million by 2010, This gro up represents 12% of the population, however, they use 25% to 40% of t he prescription medications, averaging 4.5 medications daily; 75% of t hem use over-the-counter medications as well. This population has also experienced an increase in the prescription of central nervous system (CNS) medications. Benzodiazepines are the most widely prescribed cla ss of CNS antianxiety/sedative medication. This article examines the u se of benzodiazepines in relation to physiological, pharmacokintic, an d pharmacodynamic changes of the older adult. The amnestic properties of these drugs in relation to the already decreasing cognitive functio n of the older adult are explored in relationship to the Diagnostic an d Statistical Manual of Mental Disorders, fourth edition, criteria for substance-induced persisting amnestic disorder. Copyright (C) 1998 by W.B. Saunders Company.