K. Hiraoka et al., PARADOXICAL PLEURAL RESPONSE TO ANTITUBERCULOUS CHEMOTHERAPY AND ISONIAZID-INDUCED LUPUS - REVIEW AND REPORT OF 2 CASES, Respiration, 65(2), 1998, pp. 152-155
Among 28 inpatients receiving antituberculous chemotherapies including
isoniazid (INH) and rifampicin, we found 2 patients with newly develo
ping pleural effusion in the hemithorax during the initial phase of su
ccessful chemotherapy. The analysis of the effusion fluids revealed an
elevated level of antinuclear antibody and a decreased level of total
component, which are findings compatible with lupus pleuritis. The pe
ripheral lymphocyte stimulation test using INH was positive in 1 patie
nt. To the best of our knowledge, there has been no published disussio
n of the relationship between a paradoxical response to antituberculou
s treatment and INH-induced lupus.