RANDOMIZED CLINICAL-TRIAL OF THE EFFECT OF PRENATAL FLUORIDE SUPPLEMENTS IN PREVENTING DENTAL-CARIES

This randomized, double-blind study tested the caries-preventive effic acy of prenatal fluoride supplementation in 798 children followed unti l age 5. Initially, 1,400 women in the first trimester of pregnancy re siding in communities served by fluoride-deficient drinking water were randomly assigned to one of two groups. During the last 6 months of p regnancy the treatment group received 1 mg fluoride daily in the form of a tablet and the control group received a placebo. Both treatment a nd control subjects were encouraged to use postnatal dietary fluoride supplements. Caries was measured in children at ages 3 and 5 while flu orosis was assessed at age 5. Caries activity was very low in both stu dy groups: 92% of children remained caries-free in the treatment group and 91% remained caries-free in the placebo group. Fluorosis was obse rved in 26 subjects, all classified as very mild. Overall, there were no statistically significant differences in the study groups with resp ect to caries and fluorosis in deciduous teeth. The study had sufficie nt power to detect an absolute risk reduction of 5.1% while only a 1.5 % reduction was observed. These findings do not support the hypothesis that prenatal fluoride has a strong caries-preventive effect.