NEUROTROPHIC FACTORS DECREASE THE RELEASE OF CREATINE-KINASE AND PROSTAGLANDIN E-2 FROM METABOLICALLY STRESSED MUSCLE

We have used an in vitro model of oxidative stress by exposing rat mus cle to 2:4 dinitrophenol. This causes an efflux of creatine kinase (CK ) and prostaglandin E-2 (PGE(2)) commonly used as indicators of muscle cell damage. We then investigated compounds with a putative cell prot ective effect in the system. Ciliary neurotrophic factor, brain derive d neurotrophic factor and insulin like growth factor 1 all prevent the release of PGE(2) and CK. To the extent that these indicators may ref lect cell damage, the results might support the investigation of the t herapeutic potential of these compounds in muscle disease. (C) 1998 El sevier Science B.V.