RECURRENT EPISODES OF HYPERPYREXIA CAUSED BY HEREDITARY SENSORIC AND AUTONOMIC NEUROPATHY TYPE-IV

History: Hereditary sensoric and autonomic neuropathy type IV (HSAN IV ) is a rare autosomal recessiv disease. Clinical manifestations includ e insensivity to pain, unpredictable rises of temperature, anhydrosis, mental retardation with muscular hypotonia, skin blotching and absenc e of histamine flare. Case report: In two twins presenting with high f ever we could confirm this diagnosis. Discussion: In patients presenti ng with recurrent episodes of otherwise unexplicable fever the lack of sensivitiy to pain could give the decisive hint to this unusual neuro pathy.