This research report describes our studies on functional vesicles as m
odels of more complex liposomes finalized to control the permeability
of the bilayer to transition metal ions and lanthanides as well as the
possibility to achieve chemical differentiation of the interior/exter
ior of the vesicular membrane. For this purpose we have utilized funct
ional lipids and have synthesized novel oligopeptides as chemical devi
ces for the tuneable control of the permeability of unilamellar vesicl
es.