T. Yabe et al., RECOGNITION OF OSTEOPONTIN BY RAT BONE-MARROW-DERIVED OSTEOBLASTIC PRIMARY-CELLS, Bioscience, biotechnology, and biochemistry, 61(4), 1997, pp. 754-756
To study the role of osteopontin,,ve did cell adhesion and ALP assays
of rat bone marrow osteoblastic cells (RBMO) on collagen Type I and os
teopontin surfaces. The RBMO proved to adhere much more strongly to th
e osteopontin and to have higher ALP activity on the osteopontin, whic
h suggests that pre-osteoblasts differentiate into osteoblasts that fo
rm bone by recognizing osteopontins.