SYNTHESIS OF SOME NOVEL NITROGENOUS FUROCOUMARIN DERIVATIVES

Reaction of 5-chloro-6-formylfurocoumarins (3 and 4) with heterocyclic amines and hydrazine derivatives yields corresponding 5-N-substituted and 5-chloro-6-hydrazine derivatives 7a-h and 8a-h, respectively. B e rgapten(5,6-c)isoxazole (9) or 6-oxime derivative 10 were obtained by reaction of 3 and 4 with hydroxylamine hydrochloride. Also, reaction o f 5-hydroxybergapten (1) and 5-hydroxyisopimpinellin (2) with aliphati c, heterocyclic and aromatic amines beside benzenesulphonamide derivat ives affords some novel 5- and 6-substituted aminofurocoumarins 11a-o, 12a-f, and 13a-f. The antimicrobial activity of all compounds was stu died.