Background. Advanced age increases the risk of any major surgical inte
rvention, particularly esophageal resection. High morbidity and increa
sed mortality have been reported in operations for esophageal cancer i
n the elderly. Methods. To determine outcome, risk factors, and the ad
visability of esophageal resection in the elderly, a single-institutio
n retrospective review was performed of esophagectomy for cancer over
a 14-year period. From January 1, 1980, to December 31, 1993, 540 pati
ents underwent esophageal resection for esophageal cancer. These patie
nts were divided into two groups: group 1, n = 89, patients 70 years o
f age or older; and group 2, n = 451, patients younger than 70 years o
f age. The two groups were compared according to preoperative risk fac
tors, morbidity rate, mortality rate, mean stay in the hospital after
operation, and long-term survival. Results. Adenocarcinoma of the esop
hagogastric junction was the most common tumor in group 1 and was usua
lly managed with a single incisional approach. There were no significa
nt differences between the groups concerning morbidity (24.7% in group
1), mortality (7.8% in group 1), mean stay in the hospital (23.3 days
in group 1), or long-term survival (59%, 23%, and 13% at 1, 3, and 5
years, respectively, in group 1). Conclusions. These results suggest t
hat esophagectomy can be performed in selected elderly patients withou
t increasing morbidity or mortality and with long-term survival. (C) 1
997 by The Society of Thoracic Surgeons.