SOME NEW BIOLOGICALLY-ACTIVE QUINOLINE ANALOGS

Two series of new quinoline derivatives have been-prepared by treating 2-methyl-4-chloroquinolines (V) and 2-methyl-4-chloroacetyloxyquinoli nes (VI) with sodium salts of 2-arylamino-5-mercapto-1,3,4-thiadiazole s (III) to give 2-arylamino-1,3,4-thiadiazol-5-thio-yl)-quinolines (VI Ia-g) and mino-1,3,4-thiadiazol-5-thio-acetyloxy)-quinolines (VIIIa-g) . The compounds have been tested for antifungal activity against Helmi ntho-sporum species, antibacterial against Bacillus subtilis and antiv iral against Tobacco Mosaic Virus (TMV) invitro in its respective host Datura stramonuim L.