INHIBITORY EFFECT OF BACTERIAL ATTACHMENT ON CANDIDAL GROWTH DUE TO ADHERENCE WITH MANNOSE-SENSITIVE PILI

A bacterial strain with affinity to Candida albicans was successfully obtained from a natural environment. An uncovered Petri dish containin g a suspension of heat-killed C. albicans cells was allowed to stand i n a laboratory for several days. Some bacteria which had adhered to th e candidal cells were tested for their ability to agglutinate the cell s. A bacterial strain, designated later as CAB-1, was found to aggluti nate candidal cells through bridging by mannose-sensitive pill, CAB-1 showed similar bacteriological characteristics to those of Citrobacter freundii by ID test. The adherence of CAB-1 to candidal cell was prec isely presented by scanning electron microscopy, The inhibitory effect of CAB-1 attachment to candidal cells on the growth of Candida was al so preliminarily confirmed.