APOPTOSIS IN THE STRIATUM OF RATS FOLLOWING INTRAPERITONEAL INJECTIONOF 3-NITROPROPIONIC ACID

Authors
SATO S GOBBEL GT HONKANIEMI J LI YB KONDO T MURAKAMI K SATO M COPIN JC CHAN PH
Citation
S. Sato et al., APOPTOSIS IN THE STRIATUM OF RATS FOLLOWING INTRAPERITONEAL INJECTIONOF 3-NITROPROPIONIC ACID, Brain research, 745(1-2), 1997, pp. 343-347
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
745
Issue
1-2
Year of publication
1997
Pages
343 - 347
Database
ISI
SICI code
0006-8993(1997)745:1-2<343:AITSOR>2.0.ZU;2-8
Abstract
The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxi n, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typica l of apoptosis was present in the DNA of cells from the striatum of 3- NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end la beling. The data suggest that striatal cells die by apoptosis followin g administration of 3-NP.