APOLIPOPROTEIN-E, TRANSTHYRETIN AND ACTIN IN THE CSF OF ALZHEIMERS PATIENTS - RELATION WITH THE SENILE PLAQUES AND CYTOSKELETON BIOCHEMISTRY

Citation
A. Merched et al., APOLIPOPROTEIN-E, TRANSTHYRETIN AND ACTIN IN THE CSF OF ALZHEIMERS PATIENTS - RELATION WITH THE SENILE PLAQUES AND CYTOSKELETON BIOCHEMISTRY, FEBS letters, 425(2), 1998, pp. 225-228
Citations number
33
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
ISSN journal
00145793
Volume
425
Issue
2
Year of publication
1998
Pages
225 - 228
Database
ISI
SICI code
0014-5793(1998)425:2<225:ATAAIT>2.0.ZU;2-U
Abstract
We measured the levels of two beta-amyloid (A beta)-sequestering prote ins, apolipoprotein (Apo) E and transthyretin (TTR), in ventricular hu man cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients and controls in relation to brain histological findings. We also studied actin levels in CSF as a marker of the biochemical role of these two p roteins in the cytoskeleton. We show that TTR levels in CSF were signi ficantly decreased in AD patients compared to controls and negatively correlated with the senile plaque (SP) abundance. Moreover, actin leve ls were positively linked to TTR levels and increased in CSF samples o f patients homozygous for the ApoE epsilon 4-allele. We propose that T TR and ApoE4 may have competition in the aggregation of A beta and its deposition in the SP of AD brain. The relationships between ApoE, TTR and actin could suggest a metabolic implication of ApoE genetics and TTR levels in cytoskeletal biochemistry which may be relevant to the p athogenesis of AD. (C) 1998 Federation of European Biochemical Societi es.