Hw. Shen et al., A LASTING CHANGE IN TRAZODONE RESPONSE AFTER NONCONVULSIVE ELECTROSHOCK THERAPY FOR MEDICATION-RESISTANT SENILE DEPRESSION, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 52(1), 1998, pp. 111-113
A senile patient showed a dramatic recovery from medication-resistant
depression after non-convulsive electroshock therapy (nc-EST), with a
lasting change in response to trazodone, which mainly acts as a seroto
nin re-uptake inhibitor. This result suggests that a change in the ser
otonin reuptake mechanism may be involved in the effect of nc-EST on d
epression.