PHOSPHOLAMBAN DOMAIN-I CYTOCHROME B(5) TRANSMEMBRANE SEQUENCE CHIMERAS DO NOT INHIBIT SERCA2A

Authors
KIMURA Y ASAHI M KURZYDLOWSKI K TADA M MACLENNAN DH
Citation
Y. Kimura et al., PHOSPHOLAMBAN DOMAIN-I CYTOCHROME B(5) TRANSMEMBRANE SEQUENCE CHIMERAS DO NOT INHIBIT SERCA2A, FEBS letters, 425(3), 1998, pp. 509-512
Citations number
25
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
425
Issue
3
Year of publication
1998
Pages
509 - 512
Database
ISI
SICI code
0014-5793(1998)425:3<509:PDCBTS>2.0.ZU;2-B
Abstract
A series of chimeras between the transmembrane domains of phospholamba n (PLN) and cytochrome b(5) were coexpressed with the Ca2+-ATPase of c ardiac sarcoplasmic reticulum (SERCA2a), The chimeric molecules were n ot inhibitory, in line with our view that inhibitory PLN/SERCA2a inter actions occur in transmembrane sequences, while cytoplasmic interactio ns regulate the inhibitory interactions in a four-base circuit. (C) 19 98 Federation of European Biochemical Societies.