Y. Kimura et al., PHOSPHOLAMBAN DOMAIN-I CYTOCHROME B(5) TRANSMEMBRANE SEQUENCE CHIMERAS DO NOT INHIBIT SERCA2A, FEBS letters, 425(3), 1998, pp. 509-512
A series of chimeras between the transmembrane domains of phospholamba
n (PLN) and cytochrome b(5) were coexpressed with the Ca2+-ATPase of c
ardiac sarcoplasmic reticulum (SERCA2a), The chimeric molecules were n
ot inhibitory, in line with our view that inhibitory PLN/SERCA2a inter
actions occur in transmembrane sequences, while cytoplasmic interactio
ns regulate the inhibitory interactions in a four-base circuit. (C) 19
98 Federation of European Biochemical Societies.