NONADHESIVE LIQUID EMBOLIC AGENT - ROLE OF ITS COMPONENTS IN HISTOLOGIC-CHANGES IN EMBOLIZED ARTERIES

Rationale and Objectives. The authors evaluated the safety and efficac y of a nonadhesive liquid embolic material and the role of its compone nts in histologic changes in embolized arteries. Materials and Methods . A Eudragit-E mixture (Rohm Chemische Fabrik, Darmstadt, Germany) was made of a cationic copolymer (Eudragit-E) dissolved in an equal volum e of absolute ethanol and iopamidol. The Eudragit-E mixture, an ethano l-iopamidol mixture, and an iopamidol-saline mixture were injected int o 12 rabbit renal arteries each. Three rabbits from each group were fo llowed up for 1 day, I week, 1 month, and 3 months, at which time they were sacrificed. Kidneys were removed for histologic examination. Res ults. The Eudragit-E mixture occluded all renal arteries without diffi culty; the arteries did not recanalize. Histologically, acute vasculit is was caused by both the Eudragit-E and ethanol-iopamidol mixtures, b ut not by the iopamidol-saline mixture. Small infarctions were elicite d with the ethanol-iopamidol mixture but not with the iopamidol-saline mixture. Conclusion. The Eudragit-E mixture is effective and easy to handle. Fifty percent ethanol may play a role in vessel occlusion with Eudragit-E mixture and in acute vasculitis.