HIGHLY EFFICIENT CATALYSTS DERIVED FROM PLANAR CHIRAL FERROCENES FOR ASYMMETRIC TRANSFER HYDROGENATION OF KETONES

Authors
DU XD DAI LX HOU XL XIA LJ TANG MH
Citation
Xd. Du et al., HIGHLY EFFICIENT CATALYSTS DERIVED FROM PLANAR CHIRAL FERROCENES FOR ASYMMETRIC TRANSFER HYDROGENATION OF KETONES, Chinese journal of chemistry, 16(1), 1998, pp. 90-93
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Chinese journal of chemistry → ACNP
ISSN journal
1001604X
Volume
16
Issue
1
Year of publication
1998
Pages
90 - 93
Database
ISI
SICI code
1001-604X(1998)16:1<90:HECDFP>2.0.ZU;2-O
Abstract
Planar chiral ferrocenes 1 and its diastereoisomer 2 were found to be good ligands for the ruthenium catalyzed asymmetric transfer hydrogena tion of ketones with i-PrOH as hydrogen source under refluxing in the presence of sodium hydroxide. The results showed that the absolute con figuration of alcohol seemed to be governed by the central chirality i n the oxazoline ring instead of the planar chirality. At a ratio of 1: 2 for Ru:ligand, 3000:1 S/C and >100,000/h(-1) TOF were observed for a cetophenone. For propiophenone 99% yield and 85% e.e. were obtained.