M. Malaguarnera et al., INTERFERON ALPHA-INDUCED DEPRESSION IN CHRONIC HEPATITIS-C PATIENTS -COMPARISON BETWEEN DIFFERENT TYPES OF INTERFERON-ALPHA, Neuropsychobiology, 37(2), 1998, pp. 93-97
IFN alpha treatment is able to produce dose-related side effects, such
as depression, in the central nervous system. We assessed the effects
on depression of four different types of IFN alpha (recombinant IFN a
lpha 2a, recombinant IFN alpha 2b, lymphoblastoid IFN alpha, leukocyte
IFN alpha), administered at the same doses in four homogeneous groups
of chronic hepatitis C patients (96 patients; 24 patients for each gr
oup). A group of 18 untreated hepatitis C patients was considered as a
control group. Depression was measured using Zung's self-rating depre
ssion scale (SDS scale) before starting IFN alpha therapy and at the I
st, 3rd and 6th month of treatment. In all patients evaluated, mean SD
S values increased from mild to moderate depression, but never attaine
d severe depression (SDS >70). More elevated SDS values were observed
in the 1st month of treatment, with a progressive decrease during the
end points above-mentioned. The recombinant IFN alpha 2a and lymphobla
stoid IFN alpha arms presented higher SDS mean scores compared to the
recombinant IFN alpha 2b and leukocyte IFN alpha arm. Only in the leuk
ocyte IFN alpha arm SDS values returned to basal values at the 6-month
end point. Leukocyte IFN alpha seemed to present a more elevated tole
rability than other IFN alpha types available for clinical practice. A
very careful selection of hepatitis C patients is required before sta
rting IFN alpha therapy.