AN ENGINEERING MODEL OF DYNAMIC CARDIOMYOPLASTY - II - CLINICAL-APPLICATIONS

Previously, a modification to the Sunagawa engineering model for the i solated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty patients, we predicted human stroke volume using the m odel with human clinical data from the literature. Predicted stroke vo lume correlated well with published stroke volume in patients who have had the dynamic cardiomyoplasty procedure. These results suggest that the modest hemodynamic improvement commonly reported after the proced ure is performed may be due to diminished latissimus dorsi strength af ter transformation. The validity of both the original Sunagawa model a nd the previously proposed modification for dynamic cardiomyoplasty is further supported with these results. A nomogram methodology for pred icting stroke volume after dynamic cardiomyoplasty for any particular patient is presented. (C) 1998 Biomedical Engineering Society.